|
|
|
|
||
        |  |
 |
|
|
 |
|
 |
||||||||
|
||||||||||
|
|
|
|
|||||||
|
||||||||||
|
Graphical contents list • MISCELLANEOUS PDF (606 K) | |||
|
Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors • SHORT COMMUNICATION Tae-Sook Jeong, Kyung Soon Kim, So-Jin An, Kyung-Hyun Cho, Sangku Lee and Woo Song Lee SummaryPlus | Full Text + Links | PDF (240 K) | |||
|
Novel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor • SHORT COMMUNICATION Tae-Sook Jeong, Kyung Soon Kim, Ju-Ryoung Kim, Kyung-Hyun Cho, Sangku Lee and Woo Song Lee SummaryPlus | Full Text + Links | PDF (298 K) | |||
|
Synthesis and characterization of bifunctional probes for the specific labeling of fusion proteins • SHORT COMMUNICATION Maik Kindermann, India Sielaff and Kai Johnsson SummaryPlus | Full Text + Links | PDF (291 K) | |||
|
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists • SHORT COMMUNICATION Richard Chesworth, Michael P. Zawistoski, Bruce A. Lefker, Kimberly O. Cameron, Robert F. Day, F. Michael Mangano, Robert L. Rosati, Stacy Colella, Donna N. Petersen, Amy Brault et al. SummaryPlus | Full Text + Links | PDF (283 K) | |||
|
Initial structure–activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist • SHORT COMMUNICATION Brian H. Heasley, Renata Jarosz, Kevin R. Lynch and Timothy L. Macdonald SummaryPlus | Full Text + Links | PDF (297 K) | |||
|
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs • SHORT COMMUNICATION Seongkon Kim, Jane Wu, Helen Y. Chen, Elizabeth T. Birzin, Wanda Chan, Yi Tien Yang, Lawrence Colwell, Susan Li, Johanna Dahllund, Frank DiNinno et al. SummaryPlus | Full Text + Links | PDF (271 K) | |||
|
Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates • SHORT COMMUNICATION Jay M. Matthews, William J. Hoekstra, Alexey B. Dyatkin, Leonard R. Hecker, Dennis J. Hlasta, Brenda L. Poulter, Patricia Andrade-Gordon, Lawrence de Garavilla, Keith T. Demarest, Eric Ericson et al. SummaryPlus | Full Text + Links | PDF (334 K) | |||
|
Studies on aromatic compounds: inhibition of calpain I by biphenyl derivatives and peptide-biphenyl hybrids • SHORT COMMUNICATION Ana Montero, Mercedes Alonso, Esperanza Benito, Antonio Chana, Enrique Mann, José M. Navas and Bernardo Herradón SummaryPlus | Full Text + Links | PDF (291 K) | |||
|
Design and synthesis of benzofused heterocyclic RXR modulators • SHORT COMMUNICATION D. L. Gernert, D. A. Neel, M. F. Boehm, M. D. Leibowitz, D. A. Mais, P. Y. Michellys, D. Rungta, A. Reifel-Miller and T. A. Grese SummaryPlus | Full Text + Links | PDF (276 K) | |||
|
Synthesis and structure–activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT2A/2C receptor antagonists • SHORT COMMUNICATION José Cid, José M. Alonso, José I. Andrés, Javier Fernández, Pilar Gil, Laura Iturrino, Encarna Matesanz, Theo F. Meert, Anton Megens, Victor K. Sipido and Andrés A. Trabanco SummaryPlus | Full Text + Links | PDF (334 K) | |||
|
Synthesis of new fluoroquinolones and evaluation of their in vitro activity on Toxoplasma gondii and Plasmodium spp. • SHORT COMMUNICATION G. Anquetin, M. Rouquayrol, N. Mahmoudi, M. Santillana-Hayat, R. Gozalbes, J. Greiner, K. Farhati, F. Derouin, R. Guedj and P. Vierling SummaryPlus | Full Text + Links | PDF (266 K) | |||
|
The significant effect of the carbohydrate structures on the DNA photocleavage of the quinoxaline–carbohydrate hybrids • SHORT COMMUNICATION Kazunobu Toshima, Tomohiro Ozawa, Tomonori Kimura and Shuichi Matsumura SummaryPlus | Full Text + Links | PDF (282 K) | |||
|
Synthesis of OSW-1 analogs with modified side chains and their antitumor activities • SHORT COMMUNICATION Lehua Deng, Hao Wu, Biao Yu, Manrong Jiang and Jiarui Wu SummaryPlus | Full Text + Links | PDF (273 K) | |||
|
In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent • SHORT COMMUNICATION Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Fuminori Hyodo, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa et al. SummaryPlus | Full Text + Links | PDF (331 K) | |||
|
2,4-Bis(octadecanoylamino)benzenesulfonic acid sodium salt as a novel scavenger receptor inhibitor with low molecular weight • SHORT COMMUNICATION Kazuya Yoshiizumi, Fumio Nakajima, Rika Dobashi, Noriyasu Nishimura and Shoji Ikeda SummaryPlus | Full Text + Links | PDF (273 K) | |||
|
1- And 2-substituted naphthalenes: a new class of potential hypotensive agents • SHORT COMMUNICATION Vishnu K. Tandon, Kunwar A. Singh and Gajendra K. Goswamy SummaryPlus | Full Text + Links | PDF (253 K) | |||
|
Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand • SHORT COMMUNICATION Marc Nazaré, Hans Matter, Otmar Klingler, Fahad Al-Obeidi, Herman Schreuder, Gerhard Zoller, Jörg Czech, Martin Lorenz, Angela Dudda, Anusch Peyman et al. SummaryPlus | Full Text + Links | PDF (262 K) | |||
|
Direct superoxide anion scavenging by a highly water-dispersible carotenoid phospholipid evaluated by electron paramagnetic resonance (EPR) spectroscopy • SHORT COMMUNICATION Bente Jeanette Foss, Hans-Richard Sliwka, Vassilia Partali, Arturo J. Cardounel, Jay L. Zweier and Samuel F. Lockwood SummaryPlus | Full Text + Links | PDF (366 K) | |||
|
Synthesis of novel fluorescent-labelled dinucleoside polyphosphates • SHORT COMMUNICATION Michael Wright and Andrew D. Miller SummaryPlus | Full Text + Links | PDF (429 K) | |||
|
Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors • SHORT COMMUNICATION Andrew Baxter, Steve Brough, Anne Cooper, Eike Floettmann, Steve Foster, Christine Harding, Jason Kettle, Tom McInally, Craig Martin, Michelle Mobbs et al. SummaryPlus | Full Text + Links | PDF (385 K) | |||
|
Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel • SHORT COMMUNICATION Stefan Peukert, Joachim Brendel, Bernard Pirard, Carsten Strübing, Heinz-Werner Kleemann, Thomas Böhme and Horst Hemmerle SummaryPlus | Full Text + Links | PDF (295 K) | |||
|
Stability studies of C-4′,6′ acetal benzylmaltosides synthesized as inhibitors of smooth muscle cell proliferation • SHORT COMMUNICATION Scott C. Mayer, William Gallaway, John Kulishoff, Maisheng Yin, Vidya Gadamasetti and Robert Mitchell SummaryPlus | Full Text + Links | PDF (274 K) | |||
|
A facile route to dynamic glycopeptide libraries based on disulfide-linked sugar–peptide coupling • SHORT COMMUNICATION Shinsuke Sando, Atsushi Narita and Yasuhiro Aoyama SummaryPlus | Full Text + Links | PDF (437 K) | |||
|
The oxime bond formation as an efficient chemical tool for the preparation of 3′,5′-bifunctionalised oligodeoxyribonucleotides • SHORT COMMUNICATION Om Prakash Edupuganti, Olivier Renaudet, Eric Defrancq and Pascal Dumy SummaryPlus | Full Text + Links | PDF (272 K) | |||
|
Solid-phase synthesis of kojic acid-tripeptides and their tyrosinase inhibitory activity, storage stability, and toxicity • SHORT COMMUNICATION Hanyoung Kim, Jaehui Choi, Jin Ku Cho, Sun Yeou Kim and Yoon-Sik Lee SummaryPlus | Full Text + Links | PDF (264 K) | |||
|
PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues • SHORT COMMUNICATION Belinda M. Abbott and Philip E. Thompson SummaryPlus | Full Text + Links | PDF (269 K) | |||
|
Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors • SHORT COMMUNICATION Jaeseung Kim and Scott McN. Sieburth SummaryPlus | Full Text + Links | PDF (266 K) | |||
|
Design, synthesis and structure–activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity • SHORT COMMUNICATION Akihiko Tanitame, Yoshihiro Oyamada, Keiko Ofuji, Yoko Kyoya, Kenji Suzuki, Hideaki Ito, Motoji Kawasaki, Kazuo Nagai, Masaaki Wachi and Jun-ichi Yamagishi SummaryPlus | Full Text + Links | PDF (318 K) | |||
|
Potent DNA gyrase inhibitors; novel 5-vinylpyrazole analogues with Gram-positive antibacterial activity • SHORT COMMUNICATION Akihiko Tanitame, Yoshihiro Oyamada, Keiko Ofuji, Kenji Suzuki, Hideaki Ito, Motoji Kawasaki, Masaaki Wachi and Jun-ichi Yamagishi SummaryPlus | Full Text + Links | PDF (250 K) | |||
|
Chemo- and stereoselective synthesis of benzocycloheptene and 1-benzoxepin derivatives as  -sympathomimetic and anorexigenic agents • SHORT COMMUNICATIONVishnu K. Tandon, Kunwar A. Singh, Anoop K. Awasthi, J. M. Khanna, Bansi Lal and Nitya Anand SummaryPlus | Full Text + Links | PDF (250 K) | |||
|
3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of 5-containing GABAA receptors • SHORT COMMUNICATION Helen J. Szekeres, John R. Atack, Mark S. Chambers, Susan M. Cook, Alison J. Macaulay, Gopalan V. Pillai and Angus M. MacLeod SummaryPlus | Full Text + Links | PDF (274 K) | |||
|
Antimelanomal activity of the copper(II) complexes of 1-substituted 5-amino-imidazole ligands against B16F10 mouse melanoma cells • SHORT COMMUNICATION Uday Sandbhor, Pallavi Kulkarni, Subhash Padhye, Gopal Kundu, Grahame Mackenzie and Robin Pritchard SummaryPlus | Full Text + Links | PDF (340 K) | |||
|
Synthesis of jaspaquinol and effect on viability of normal and malignant bladder epithelial cell lines • SHORT COMMUNICATION Alexandre Demotie, Ian J. S. Fairlamb, Feng-Ju Lu, Nicola J. Shaw, Peter A. Spencer and Jennifer Southgate SummaryPlus | Full Text + Links | PDF (290 K) | |||
|
Synthesis and biological activity of novel platinum(II) complexes of glutamate tethered to hydrophilic hematoporphyrin derivatives • SHORT COMMUNICATION Yeong-Sang Kim, Rita Song, Chong Ock Lee and Youn Soo Sohn SummaryPlus | Full Text + Links | PDF (264 K) | |||
|
Structure–activity relationships of trans-cinnamic acid derivatives on -glucosidase inhibition • SHORT COMMUNICATION Sirichai Adisakwattana, Kasem Sookkongwaree, Sophon Roengsumran, Amorn Petsom, Nattaya Ngamrojnavanich, Warinthorn Chavasiri, Sujitra Deesamer and Sirintorn Yibchok-anun SummaryPlus | Full Text + Links | PDF (252 K) | |||
|
Reverse hydroxamate-based selective TACE inhibitors • SHORT COMMUNICATION Noriyuki Kamei, Tomohiro Tanaka, Kentaro Kawai, Kyosei Miyawaki, Akihiko Okuyama, Yoshiko Murakami, Yoshio Arakawa, Makoto Haino, Tatsuhiro Harada and Masanao Shimano SummaryPlus | Full Text + Links | PDF (278 K) | |||
|
Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents • SHORT COMMUNICATION Vishnu K. Tandon, Ravindra V. Singh and Dharmendra B. Yadav SummaryPlus | Full Text + Links | PDF (254 K) | |||
|
N-Aryl- -lactams as integrin v 3 antagonists • SHORT COMMUNICATIONNing Xi, Stephen Arvedson, Shawn Eisenberg, Nianhe Han, Michael Handley, Liang Huang, Qi Huang, Alexander Kiselyov, Qingyian Liu, Yuelie Lu et al. SummaryPlus | Full Text + Links | PDF (290 K) | |||
|
Synthesis and biological activity of some structural modifications of pancratistatin • SHORT COMMUNICATION Uwe Rinner, Heather L. Hillebrenner, David R. Adams, Tomas Hudlicky and George R. Pettit SummaryPlus | Full Text + Links | PDF (269 K) | |||
|
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and 2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety • SHORT COMMUNICATION Joaquín Pastor, Jesús Alcázar, Rosa M. Alvarez, J. Ignacio Andrés, José M. Cid, Ana I. De Lucas, Adolfo Díaz, Javier Fernández, Luis M. Font, Laura Iturrino et al. SummaryPlus | Full Text + Links | PDF (380 K) | |||
|
New highly selective inhibitors of class II fructose-1,6-bisphosphate aldolases • SHORT COMMUNICATION Matthieu Fonvielle, Philippe Weber, Kasia Dabkowska and Michel Therisod SummaryPlus | Full Text + Links | PDF (265 K) | |||
|
Synthesis and DNA binding properties of dioxime–peptide nucleic acids • SHORT COMMUNICATION Andriy Mokhir, Roland Krämer, Yan Z. Voloshin and Oleg A. Varzatskii SummaryPlus | Full Text + Links | PDF (275 K) | |||
|
Plasmepsin II inhibition and antiplasmodial activity of Primaquine–Statine ‘double-drugs' • SHORT COMMUNICATION Sergio Romeo, Mario Dell'Agli, Silvia Parapini, Luca Rizzi, Germana Galli, Monica Mondani, Anna Sparatore, Donatella Taramelli and Enrica Bosisio SummaryPlus | Full Text + Links | PDF (253 K) | |||
|
Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine derivatives • SHORT COMMUNICATION Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya, Yumiko Hirokawa, Taketoshi Furugori and Takayasu Nagahara SummaryPlus | Full Text + Links | PDF (262 K) | |||
|
The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase • SHORT COMMUNICATION Mark T. Bilodeau, Leonard D. Rodman, Georgia B. McGaughey, Kathleen E. Coll, Timothy J. Koester, William F. Hoffman, Randall W. Hungate, Richard L. Kendall, Rosemary C. McFall, Keith W. Rickert et al. SummaryPlus | Full Text + Links | PDF (299 K) | |||
|
Synergetic inhibition of genistein and -glucosidase • SHORT COMMUNICATION Yufang Wang, Lin Ma, Chaole Pang, Minju Huang, Zhishu Huang and Lianquan Gu SummaryPlus | Full Text + Links | PDF (352 K) | |||
|
Design, synthesis, and characterization of an ATP-peptide conjugate inhibitor of protein kinase A • SHORT COMMUNICATION Aliya C. Hines and Philip A. Cole SummaryPlus | Full Text + Links | PDF (262 K) | |||
|
Identification of purine inhibitors of phosphodiesterase 7 (PDE7) • SHORT COMMUNICATION William J. Pitts, Wayne Vaccaro, Tram Huynh, Katerina Leftheris, Jacques Y. Roberge, Joseph Barbosa, Junqing Guo, Baerbel Brown, Andrew Watson, Karen Donaldson et al. SummaryPlus | Full Text + Links | PDF (275 K) | |||
|
Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices • SHORT COMMUNICATION Ichiro Suzuki, Shinsaku Uno, Yuko Tsuchiya, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya SummaryPlus | Full Text + Links | PDF (267 K) | |||
|
Design, synthesis, and structure–activity relationship of new isobenzofuranone ligands of protein kinase C • SHORT COMMUNICATION Yoshiyasu Baba, Yosuke Ogoshi, Go Hirai, Takeshi Yanagisawa, Kumiko Nagamatsu, Satoshi Mayumi, Yuichi Hashimoto and Mikiko Sodeoka SummaryPlus | Full Text + Links | PDF (388 K) | |||
|
Evaluation of series of isobenzofuranone dimers as PKC ligands: implication for the distance between the two ligand binding sites • SHORT COMMUNICATION Yoshiyasu Baba, Satoshi Mayumi, Go Hirai, Hidekazu Kawasaki, Yosuke Ogoshi, Takeshi Yanagisawa, Yuichi Hashimoto and Mikiko Sodeoka SummaryPlus | Full Text + Links | PDF (271 K) | |||
|
Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases • SHORT COMMUNICATION Raj N. Misra, Hai-yun Xiao, David K. Williams, Kyoung S. Kim, Songfeng Lu, Kristen A. Keller, Janet G. Mulheron, Roberta Batorsky, John S. Tokarski, John S. Sack et al. SummaryPlus | Full Text + Links | PDF (310 K) | |||
|
Antitumor agents. Part 230: C4′-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors • SHORT COMMUNICATION Shiqing Han, Zhiyan Xiao, Kenneth F. Bastow and Kuo-Hsiung Lee SummaryPlus | Full Text + Links | PDF (305 K) | |||
|
Synthesis of dammarane-type triterpenoids with anti-inflammatory activity in vivo • SHORT COMMUNICATION Dieter Scholz, Karl Baumann, Max Grassberger, Barbara Wolff-Winiski, Grety Rihs, Hansrudolf Walter and Josef G. Meingassner SummaryPlus | Full Text + Links | PDF (292 K) | |||
|
Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists • SHORT COMMUNICATION Min Amy Xiang, Robert H. Chen, Keith T. Demarest, Joseph Gunnet, Richard Look, William Hageman, William V. Murray, Donald W. Combs and Mona Patel SummaryPlus | Full Text + Links | PDF (244 K) | |||
|
Corrigendum to "Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGF receptor kinase (TRI)": [Bioorg. Med. Chem. Lett. 13 (2003) 4355] • ERRATUM Juswinder Singh, Claudio E. Chuaqui, P. Ann Boriack-Sjodin, Wen-Cherng Lee, Timothy Pontz, Michael J. Corbley, H. -Kam Cheung, Robert M. Arduini, Jonathan N. Mead, Miki N. Newman et al. SummaryPlus | Full Text + Links | PDF (206 K) | |||
|
Editorial board • MISCELLANEOUS PDF (274 K) | |||
|
Contributors to this issue • MISCELLANEOUS PDF (192 K) | |||
|
Instructions to contributors • PUBLISHER'S NOTE PDF (74 K) | |||
|
|
|
|
|
|
| Copyright © 2004 Elsevier B.V. All rights reserved. ScienceDirect® is a registered trademark of Elsevier B.V. |
